stehlik-dorfleutner lab publications 2016-2020
Khare S, Radian AD, Dorfleutner A*, Stehlik C*. Measuring NLR Oligomerization I: Size Exclusion Chromatography, Co-immunoprecipitation, and Cross-Linking. Methods in Molecular Biology 2016, 1417, p131-143. PMID:27221486 | pdf
de Almeida L, Dorfleutner A*, Stehlik C*. In vivo Analysis of Neutrophil Infiltration during LPS-induced Peritonitis. Bio Protocols 2016, 6, pii:e1945. PMID:28752106 | pdf
de Almeida L, Dorfleutner A*, Stehlik C*. ASC-particle-induced Peritonitis. Bio Protocols 2016, 6, pii: e1944. PMID:28516116 | pdf
Khare S, Radian AD, Dorfleutner A*, Stehlik C*. Measuring NLR Oligomerization I: Size Exclusion Chromatography, Co-immunoprecipitation, and Cross-Linking. Methods in Molecular Biology, 2016,1417, p131-143. PMID:27221486 | pdf
Dorfleutner A*, Stehlik C*. A dRAStic RHOAdblock of Pyrin inflammasome activation. Nature Immunology 2016, 17, p900-902. PMID:27434003 | pdf
Tsai F, Homan PJ, Agrawal H, Misharin AV, Abdala-Valencia H, Haines GK 3rd, Dominguez S, Bloomfield CL, Saber R, Chang A, Mohan C, Hutcheson J, Davidson A, Budinger GRS, Bouillet P, Dorfleutner A, Stehlik C, Winter DR, Cuda CM, Perlman H. Bim suppresses the development of SLE by limiting myeloid inflammatory responses. Journal of Experimental Medicine 2017, 214, p3753-3773. PMID:29114065 | pdf
Ratsimandresy RA, Chu LH, Khare S, de Almeida L, Gangopadhyay A, Indramohan M, Misharin AV, Greaves DR, Perlman H, Dorfleutner A*, Stehlik C*. The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation. Nature Communications 2017, 8, p15556. PMID:28580931 | pdf | press coverage Northwestern University | pdf
Shi B, Huang QQ, Birkett R, Doyle R, Dorfleutner A, Stehlik C, He C, Pope RM. SNAPIN is critical for lysosomal acidification and autophagosome maturation in macrophages. Autophagy 2017, 13, p285-301. PMID:27929705 | pdf
Ratsimandresy RA, Indramohan M, Dorfleutner A*, Stehlik C*. The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway. Cellular and Molecular Immunology 2017, 14, p127-142. PMID:27524110 | pdf
Indramohan M, Stehlik C*, Dorfleutner A*. COPs and POPs Patrol Inflammasome Activation. Journal of Molecular Biology 2018, 430, p153-173. PMID:29024695 | pdf
Chu LH, Indramohan M, Ratsimandresy RA, Gangopadhyay A, Morris EP, Monack DM, Dorfleutner A*, Stehlik C*. The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages. Nature Communications 2018, 9, p996. PMID:29520027 | pdf | press coverage: Northwestern University | pdf
Viaud M, Ivanov S, Vujic N, Duta-Mare M, Aira LE, Barouillet T, Garcia E, Orange F, Dugail I, Hainault I, Stehlik C, Marchetti S, Boyer L, Guinamard R, Foufelle F, Bochem A, Hovingh KG, Thorp EB, Gautier EL, Kratky D, Dasilva-Jardine P, Yvan-Charvet L. Lysosomal Cholesterol Hydrolysis Couples Efferocytosis to Anti-Inflammatory Oxysterol Production. Circulation Research 2018, 122, p1369-1384. PMID:29523554 | pdf
Bhattacharyya S, Wang W, Qin W, Cheng K, Coulup S, Chavez S, Jiang S, Raparia K, De Almeida LMV, Stehlik C, Tamaki Z, Yin H, Varga J. TLR4-dependent fibroblast activation drives persistent organ fibrosis in skin and lung. Journal of Clinical Investigations Insight 2018, 3, pii: 98850. PMID:29997297 | pdf | highlighted by a commentary by O’Reilly, S.. and van Laar, J.M. (2018) Targeting the TLR4–MD2 axis in systemic sclerosis. Nature Reviews Rheumatology 14, p564 | pdf
Devi S, Stehlik C*, Dorfleutner A*. An Update on CARD Only Proteins (COPs) and PYD Only Proteins (POPs) as Inflammasome Regulators. International Journal of Molecular Sciences 2020, 21, p6901. PMID:32962268 | pdf
Downs KP, Nguyen H, Dorfleutner A*, Stehlik C*. An overview of the non-canonical inflammasome. Molecular Aspects of Medicine 2020, 76, p100924. PMID:33187725 | pdf