Stehlik, C., de Martin, R., Kumabashiri, I., Schmid, J.A., Binder, B.R. and Lipp, J. (1998). Nuclear Factor (NF)- kB-regulated X-chromosome-linked iap Gene Expression Protects Endothelial Cells from Tumor Necrosis Factor a-induced Apoptosis.   J. Exp. Med. 188, 211-216   I    pdf


Stehlik, C., de Martin, R., Binder, B.R. and Lipp, J. (1998). Cytokine induced expression of porcine Inhibitor of Apoptosis Protein (iap) family member is regulated by NF-kB. Biochem.    Biophys.   Res. Com. 234, 827-832   I    pdf






Hofer-Warbinek, R., Schmid, J.A., Stehlik, C., Binder, B.R., Lipp, J. and de Martin, R. (2000). Activation of NF-kappaB by XIAP, the X chromosome-linked inhibitor of apoptosis.    J. Biol. Chem. 275, 22064-22068   I    pdf






*Damiano, J.S., *Stehlik, C., Pio, F., Godzik, A., and Reed, J.C. (2001) CLAN, a novel human CED4 like gene.   *equally contributed;    Genomics 75, 77-83        I    pdf


Lee S.H., Stehlik C., Reed J.C. (2001) COP, a CARD-containing protein and inhibitor of caspase-1 activation processing.   J. Biol. Chem. 276, 34495-34500    I    pdf






Stehlik, C., Fiorentino, L., Dorfleutner,A., Bruey, J.M., Ariza, E.M., Sagara, J., and Reed, J.C. (2002) The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in NF-kB activation pathways.    J. Exp. Med. 196,1605-1615    I    pdf


*Fiorentino, L., *Stehlik, C. Oliveira, V., Ariza, M.E., Godzik, A., and Reed, J.C. (2002) A Novel PAAD-containing Protein That Modulates NF-kB Induction by Cytokines Tumor Necrosis Factor-a and Interleukin-1b.    *equally contributed;    J. Biol. Chem. 277, 35333-35340     I    pdf







Stehlik, C., Lee, S.H., Dorfleutner A., Stassinopoulos, A., Sagara, J., and Reed, J.C. (2003) Apoptosis-associated speck-like protein containing a caspase recruitment domain is a Regulator of pro-Caspase-1 Activation,  J. Immunol. 171, 6154-63    I    pdf


Reed, J.C., Doctor, K., Rojas, A., Zapata, J.M., Stehlik, C., Fiorentino, L., Damiano, J., Roth, W., Matsuzawa, S., Newman, R., Takayama, S., Marusawa, H., Xu, F., Salvesen, G., and Godzik, A. (2003) Comparative Analysis of Apoptosis and Inflammation Genes of Mice and Humans.   Genome Res.13(6B), 1376-1388    I    pdf


Stehlik, C., Hayashi, H., Pio, F., Godzik, A., and Reed, J.C. (2003) CARD6, a CARD containing inhibitor of Nod1 and Cardiak induced NF-kB activation.   J. Biol. Chem. 278, 31941-31949    I    pdf


Stehlik, C., Krajewska, M., Welsh, K., Krajewski, S., Godzik, A., and Reed, J.C. (2003) The PAAD/PYRIN-only protein POP is a modulator of ASC-mediated NF-kB and pro-Caspase-1 regulation.   Biochem. J. 372, 101-113    I   pdf

editorial: Mariathasan, S., and Vucic, D. (2003) POPing the fire into the pyrin?   Biochem. J. 372, e1-2    I    pdf






Bruey, J.M., Bruey-Sedano, N., Newman, R., Chandler, S., Stehlik, C., and Reed, J.C.  (2004) PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages.  J. Biol. Chem. 279, 51897-51907   I    pdf


Kroismayr, R., Baranyi, U., Stehlik, C., Dorfleutner, A., Binder, B.R., and Lipp, J. (2004) HERC5, a HECT E3 ubiquitin ligase tightly regulated in LPS activiated endothelial cells.   J. Cell Science 117, 4749-4756   I    pdf


Stehlik C., Kroismayr, R., Dorfleutner A., Binder B.R., and Lipp J. (2004) VIGR – a novel inducible adhesion family G-protein coupled receptor in endothelial cells.   FEBS Letters 569, 149-155   I    pdf


Stehlik, C*. and Reed, J.C. (2004) The PYRIN Connection: Novel Players in innate immunity and inflammation.    *Corresponding Author;   J. Exp. Med. 200, 551-558    I    pdf






Chanvorachote, P., Nimmanit, U., Wang, L., Stehlik, C., Lu, B., Azad, N., and Rojanasakul, Y. (2005) Nitric oxide negatively regulates Fas (CD95)-induced apoptosis through inhibition of ubiquitin-proteasome mediated degradation of FLIP.  J. Biol. Chem. 280, 42044-42050   I    pdf


Medan, D., Wang, L., Toledo, D., Lu, B., Stehlik, C., Shi, X., and Rojanasakul, Y. (2005) Regulation of Fas (CD95)-mediated apoptotic and necrotic cell death by reactive oxygen species in macrophages.   J. Cell Physiol. 203,78-84   I    pdf






Azad, N., Chanvorachote, P., Nimmanit, U., Stehlik, C., Ongpipatanakul, B., and Rojanasakul, Y. (2006). Reactive Oxygen Species-mediated S-Nitrosylation and stabilization of Bcl-2.   J. Biol.Chem., 281, 34124-34134   I    pdf


Lu, B., Wang, L., Stehlik, C., Medan, D., Huang, C., Hu, S., Chen, F., Shi, X., and Rojanasakul, Y. (2006) Phosphatidylinositol 3-Kinase/Akt Positively Regulates Fas (CD95)-Mediated Apoptosis in Epidermal Cl41 Cells.  J. Immunol. 176, 6785-6793   I    pdf


Chanvorachote, P., Nimmanit, U., Stehlik, C., Ongpipatanakul, B., and Rojanasakul, Y. (2006). Nitric Oxide Regulates Cell Sensitivity to Cisplatin-Induced Apoptosis through S-Nitrosylation and Inhibition of Bcl-2 Ubiquitination.   Cancer Res. 66, 6353-6360   I    pdf






Stehlik, C. and Dorfleutner, A. (2007) COPs & POPs: Modulators of Inflammasome Activity.   J. Immunol., 179, 7993-7998       I    pdf


Dorfleutner, A., Stehlik, C., Zhang, J., Gallick, G.E., Flynn, D.C. (2007) AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells.  J. Cell. Physiol., 213, 740-749    I    pdf


Stehlik, C. (2007) The PYRIN domain in signal transduction.   Curr. Prot. Pept. Sci., 8, 293-310    I    pdf


Dorfleutner, A., Bryan, N.B., Talbott, S.J., Fynya, K.N., Rellick, S.L., Reed, J.C., Shi, X., Royanasakul, Y., Flynn, D.C., and Stehlik, C. (2007) Cellular PYRIN domain-only protein (cPOP) 2 is a novel regulator of inflammasome activation.  Infect. Immun., 75, 1484-1492    I    pdf      I    featured as a Spotlight article in Infection and Immunity    I    pdf


Dorfleutner, A., Talbott, S.J., Bryan, N.B., Funya, K.N., Rellick, S.L., Reed, J.C., Shi, X., Flynn, D.C, Rojanasakul, Y. and Stehlik, C. (2007) A shope Fibroma virus PYRIN-only protein modulates the host immune response.    Virus Genes., 35, 685-694       I    pdf






Dorfleutner, A, Chi, Y., Vincent, D., Cunnick, J.M., Lin, H., Weed, S.A., Stehlik, C., and Flynn, D.C. (2008) Phosphorylation of AFAP-110 affects podosome lifespan in A7r5 cells.   J. Cell Sci., 121, 2394-24057   I    pdf


Wang; L., Chanvorachote, P., Toledo, D., Stehlik, C., Mercer, R.R., Castranova, V. and Rojanasakul, Y. (2008) Peroxide is a Key Mediator of Bcl-2 Downregulation and Apoptosis Induction by Cisplatin in Human Lung Cancer Cells.   Mol. Pharm., 73, 119-127   I    pdf






Stehlik, C. (2009) Multiple proteases are responsible for IL-1β maturation in inflammatory arthritis.   Arthritis & Rheum., 60, 3524-3530   I    pdf


Bryan, N.B., Dorfleutner, A., Rojanasakul, Y, and Stehlik, C. (2009) Activation of inflammasomes requires intracellular redistribution of the apoptotic speck-like protein containing a caspase recruitment domain (ASC).   J. Immunol., 182, 3173-3182   I    pdf   I    featured "in this issue"   I    pdf






Khare, S., Luc, N., Dorfleutner, A., and Stehlik, C. (2010) Inflammasomes and their activation.   Crit. Rev. Immunol, 30, 463-487   I    pdf


Azad, N., Iyer, A., Vallyathan, V., Wang, L., Castranova, V., Stehlik, C. and Rojanasakul, Y. (2010) Role of oxidative/nitrosative stress-mediated Bcl-2 regulation in apoptosis and malignant transformation.    Ann. N.Y. Acad. Sci., 1203, 1-6   I    pdf 


Bryan, N.B., Dorfleutner, A., Kramer, S.J., Yun, C., Rojanasakul, Y. and Stehlik, C. (2010) Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes.   J. Inflammation., 18, 7-23   I    pdf   I     Highly accessed article






Iyer, A.K., Azad, N., Talbot, S., Stehlik, C., Lu, B., Wang, L. and Rojanasakul, Y. (2011) Antioxidant c-FLIP inhibits Fas ligand-induced NF-kappaB activation in a phosphatidylinositol 3-kinase/Akt-dependent manner.     J. Immunol., 187, 3256-3266   I    pdf 


Stehlik, C. (2011) Macrophages, the Inflammasome and IL-1β in Cancer.   The Journal of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, XIV, 44-52   I    pdf






Huang, Q.Q., Koessler, R.E., Birkett, R., Dorfleutner, A., Perlman, H., Haines III, K.G., Stehlik, C., Nicchitta, C.V. and Pope, R.M., (2012) Gp96 perpetuates the Persistent Inflammation of Rheumatoid Arthritis.     Arthritis & Rheumatism, 64, 3638-3648   I    pdf


Khare, S., Dorfleutner, A., Bryan, N.B., Yun, C., Radian, A.D., de Almeida, L., Rojanasakul, Y., and Stehlik, C. (2012) An NLRP7-containing inflammasome mediates recognition of microbial lipopeptides in macrophages.    Immunity,  36, 464-476   I    pdf   I     Most-read article   I    pdf   I    Featured as a Research Highlight in Nature Reviews Immunology.    Nature Reviews Immunology, 12, 358   I    pdf   I    Featured as a Research Highlight in Nature Immunology.    Nature  Immunology, 13, 358    I    pdf   I    press coverage: Northwestern University   I    pdf   I    The Daily Northwestern   I    pdf   I    EurekAlert   I    pdf   I    LabSpaces   I    pdf   I    MediLexicon   I    pdf   I    Medical News Today   I    pdf   I    recommended by F1000Prime       I    pdf


Luanpitpong, S., Chanvorachote, P., Nimmannit, U., Leonard, S.S., Stehlik, C., Wang, L. and Rojanasakul, Y. (2012) Mitochondrial Superoxide Mediates Doxorubicin-Induced Keratinocyte Apoptosis through Oxidative Modification of ERK and Bcl-2 Ubiquitination.   Biochemical Pharmacology, 83, 1643-1654   I    pdf


Kung, V.L., Khare, S., Stehlik, C., Bacon, E., Hughes, A.J.,Hauser, A.R.. (2012) An rhs gene of Pseudomonas aeruginosa encodes a virulence protein that activates the inflammasome,     Proc. Nat. Acad. Sci. USA, 109, 1275-1280   I    pdf   I       Featured as a Research Highlight in Nature.   Nature, 481, 240   I    pdf


Shi, B., Huang, Q., Tak, P.P., Vervoordeldonk, M.J., Huang, C.C., Dorfleutner, A., Stehlik, C. and Pope, R.M. (2012) SNAPIN: an endogenous toll-like receptor ligand in rheumatoid arthritis.    Ann. Rheum. Dis., 71, 1411-1417    I    pdf






Ratsimandresy, R., Dorfleutner, A., Stehlik, C. (2013) An Update on PYRIN Domain-Containing Pattern Recognition Receptors: From Immunity to Pathology.    Front. Immunol., 4:440   I    pdf


Radian, A.D., Dorfleutner, A., de Almeida, L., and Stehlik, C. (2013) NLRP7 and related inflammasome activating pattern recognition receptors and their function in host defense and disease.    Microbes & Infection, 15, 630-639   I    pdf


Luanpitpong, S., Chanvorachote, P., Stehlik, C., Tse, W., Callery, P.S., Wang, L., and Rojanasakul, Y. (2013) Regulation of Apoptosis by Bcl-2 Cysteine Oxidation in Human Lung Epithelial Cells.     Mol. Biol. Cell, 24, 858-869   I    pdf






Khare, S., Ratsimandresy, R.A., de Almeida, L., Cuda, C.M., Rellick, S.L., Misharin, A.V., Wallin, M.C., Gangopadhyay, A., Forte, E., Gottwein, E., Perlman, H., Reed, J.C., Greaves, D.R., Dorfleutner, A. and Stehlik, C. (2014) The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses.   Nature Immunology, 15, 343-353   I    pdf   I    highlighted with a News and Views Commentary by Krishnaswamy J.K., Liu D. and Eisenbarth S.C. (2014) POP goes the inflammasome.   Nature Immunology, 15, 311-313   I    pdf   I    selected as the cover article   I    pdf   I    featured by the Austrian Presse Agentur (APA) and MedOnline   I    pdf   I    jimdo.com (in Italian)   I    pdf   I    Nature Asia   I    pdf   I    and Feinberg News   I    pdf


Talbott, S.J., Luanpitpong, S., Stehlik, C., Azad, N., Iyer, A.K.V., Wang, L. and Rojanasakul, Y. (2014) S-nitrosylation of FLICE inhibitory protein determines its interaction with RIP1 and activation of NF-κB.    Cell Cycle, 13, 1948-1957   I    pdf


Cuda, C.M., Misharin, A.V., Gierut, A.K., Saberr, R., Haines, G.K., Hutcheson, J., Hedrick, S.M., Mohan, C., Budinger, G.S., Stehlik, C., Perlman, H. (2014) Caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated Dendritic Cell activation.    J. Immunol., 192, 5548-5560   I    pdf   I     featured "in this issue"   I    pdf






de Almeida, L., Khare, S., Misharin, A.V., Patel, R., Wallin, M., Perlman, H.R., Greaves, D.R., Hoffman, H.M., Dorfleutner, A., and Stehlik, C. (2015) The PYRIN domain-only protein POP1 inhibits inflammasome assembly and ameliorates inflammatory disease.   Immunity 43, 264-276   I    pdf   I       Selected for display at the Immunity website   I    pdf   I    highlighted with a Commentary by Shimada K. Timothy R. Crother T.R., and Arditi, M. (2015) POPsicle for Fever! Cooling Down the Inflammasome.   Immunity, 43, 213-215   I    pdf   I    press coverage: Northwestern University   I    pdf   I    the Rheumatologist   I    pdf


Cuda, C.M., Misharin, A.V., Khare, S., Saber, R., Tsai, F., Archer, A.M., Homan, P.J., Haines III, K.G, Hutcheson, J., Dorfleutner, A., Budinger, S.G.R., Stehlik, C. and Perlman, H. (2015) Conditional deletion of caspase-8 in macrophages alters macrophage activation in a RIPK-dependent manner. Arthritis Research & Therapy, 17, 291-307   I    pdf


Radian, A.D., Khare, S., Chu, L.H., Dorfleutner, D. and Stehlik, C. (2015) ATP binding by NLRP7 is required for inflammasome activation in response to bacterial lipopeptides,    Molecular Immunology, 2015, pii: S0161-5890(15)00437-X   I    pdf


Chu, L.H., Gangopadhyay, A., Dorfleutner, A. and Stehlik, C. (2015) An updated view on the structure and function of PYRIN domains.    Apoptosis, 20,157-173   I    pdf


Dorfleutner, A. Chu, L. and Stehlik, C. (2015) Inhibiting the inflammasome: one domain at a time.   Immunol. Rev., 265, 205-216   I    pdf


Thorp, E.B., Stehlik, C. and Ansari, M.J. (2015) T-cell exhaustion in allograft rejection and tolerance.    Curr. Opin. Organ. Transplant., 20, 37-42   I    pdf


Queen, J., Agarwal, S., Dolores, J., Stehlik, C. and Satchell, K.J.F. (2015) Mechanisms of inflammasome activation by Vibrio cholerae secreted toxins varies with strain biotype.   Infection & Immunity, 83, 2496-2506   I    pdf






Khare, S. Radian, A.D., Dorfleutner, A. and Stehlik, C. (2016) Methods to measure NLR oligomerization: co-immunoprecipitation and cross-linking. in “NLR proteins: Methods and Protocols”,    Methods in Molecular Biology, Humana Press, Francesco Di Virgilio, Pablo Pelegrín (Eds.), 2016.   I    pdf


de Almeida, L., Dorfleutner, A. and Stehlik, C. (2016)  ASC-Particle-Induced Peritonitis. Bio-protocol  6(19): e1944. DOI: 10.21769/BioProtoc.1944.   I    pdf  .


de Almeida, L., Dorfleutner, A. and Stehlik, C. (2016) LPS-Induced Peritonitis. Bio-protocol 6(19): e1945. DOI: 10.21769/BioProtoc.1945.   I    pdf  .


Dorfleutner, A. and Stehlik, C. (2016)  A dRAStic RHOAdblock of Pyrin inflammasome activation. Nature Immunol., 17. 900-902.   I    pdf






Ratsimandresy, R.A., Indramohan, M., Dorfleutner, A. and Stehlik, C. (2017)  The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway.    Cellular & Molecular Immunol., 13, 127–142.   I    pdf


Shi, B., Huang, Q., Birkett, R., Doyle, R., Dorfleutner, A., Stehlik, C., He, C. and Pope, R.M. (2017) Snapin is critical for lysosomal acidification and autophagosome maturation in macrophages.   Autophagy 13, 285-301.   I    pdf


Ratsimandresy, R., Chu, H.L., Indramohan, M., Gangopadhyay, A., Dorfleutner, A., and Stehlik, C. (2017) The PYRIN domain-only protein POP2 regulates inflammasome priming and activation.    Nature Communications 8, 15556.   I    pdf.   I    press coverage: Northwestern University   I    pdf   I


Tsai, F., Homan, P.J., Agrawal, H., Misharin,A.V., Abdala-Valencia, H., Haines III, K.G., Dominguez, S., Bloomfield, C., Saber, R., Chang, A., Mohan, C., Hutcheson, J., Davidson, A.,  Budinger, S.G., Bouillet, P., Dorfleutner, A., Stehlik, C., Winter, D.R., Cuda, C.M.,and  Perlman, H. (2017)  Bim Suppresses the Development of SLE by limiting Myeloid Inflammatory Responses.   J. Exp. Med. 214, 3753-3773.   I    pdf


 Indramohan, M., Stehlik, C., and Dorfleutner, A. (2017)  COPs and POPs patrol inflammasome activation.   J. Mol. Biol. S0022-2836(17)30474-6.  I    pdf






 Viaud, M., Ivanov, S., Vujic, N., Duta-Mare, M., Aira, L.E., Barouillet, T., Garcia, E., Orange, F., Dugail, I., Hainault, I., Stehlik, C., Marchetti, S., Boyer, L., Guinamard, R., Foufelle, F., Bochem, A., Hovingh, K.G., Thorp, E.B., Gautier, E.L., Kratky, D., Dasilva-Jardine, P., Yvan-Charvet, L. (2018) Lysosomal Cholesterol Hydrolysis Couples Efferocytosis to Anti-Inflammatory Oxysterol Production.   Circulation Res. in press.   I    pdf


 Chu, H.L., Indramohan, M., Ratsaimandresy, R.A., Gangopadhyay, A., Morris, E.P., Monack, D.M., Dorfleutner, A., and Stehlik, C. (2018) The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages.   Nature Communications 9, 996.  I    pdf    I    press coverage: Northwestern University   I    pdf   I


Bhattacharyya, S., Wang, W., Qin, W., Cheng, K., Coulup, S., Chavez, S., Jiang, S., Raparia, K., De Almeida, L.M.V., Stehlik, C., Tamaki, Z., Yin, H., Varga, J.  (2018) TLR4-dependent fibroblast activation drives persistent organ fibrosis in skin and lung. JCI Insight.;3, pii: 98850.  I    pdf    I    highlighted by a commentary by O'Reilly, S.. and van Laar, J.M. (2018) Targeting the TLR4–MD2 axis in systemic sclerosis.  Nature Reviews Rheumatology 14, 564.  I    pdf    I





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