1998

 

Stehlik, C., de Martin, R., Kumabashiri, I., Schmid, J.A., Binder, B.R. and Lipp, J. (1998). Nuclear Factor (NF)- kB-regulated X-chromosome-linked iap Gene Expression Protects Endothelial Cells from Tumor Necrosis Factor a-induced Apoptosis.   J. Exp. Med. 188, 211-216   I    pdf

 

Stehlik, C., de Martin, R., Binder, B.R. and Lipp, J. (1998). Cytokine induced expression of porcine Inhibitor of Apoptosis Protein (iap) family member is regulated by NF-kB. Biochem.    Biophys.   Res. Com. 234, 827-832   I    pdf

 

 

 

2000

 

Hofer-Warbinek, R., Schmid, J.A., Stehlik, C., Binder, B.R., Lipp, J. and de Martin, R. (2000). Activation of NF-kappaB by XIAP, the X chromosome-linked inhibitor of apoptosis.    J. Biol. Chem. 275, 22064-22068   I    pdf

 

 

 

2001

 

*Damiano, J.S., *Stehlik, C., Pio, F., Godzik, A., and Reed, J.C. (2001) CLAN, a novel human CED4 like gene.   *equally contributed;    Genomics 75, 77-83        I    pdf

 

Lee S.H., Stehlik C., Reed J.C. (2001) COP, a CARD-containing protein and inhibitor of caspase-1 activation processing.   J. Biol. Chem. 276, 34495-34500    I    pdf

 

 

 

2002

 

Stehlik, C., Fiorentino, L., Dorfleutner,A., Bruey, J.M., Ariza, E.M., Sagara, J., and Reed, J.C. (2002) The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in NF-kB activation pathways.    J. Exp. Med. 196,1605-1615    I    pdf

 

*Fiorentino, L., *Stehlik, C. Oliveira, V., Ariza, M.E., Godzik, A., and Reed, J.C. (2002) A Novel PAAD-containing Protein That Modulates NF-kB Induction by Cytokines Tumor Necrosis Factor-a and Interleukin-1b.    *equally contributed;    J. Biol. Chem. 277, 35333-35340     I    pdf

 

 

 

 

2003

 

Stehlik, C., Lee, S.H., Dorfleutner A., Stassinopoulos, A., Sagara, J., and Reed, J.C. (2003) Apoptosis-associated speck-like protein containing a caspase recruitment domain is a Regulator of pro-Caspase-1 Activation,  J. Immunol. 171, 6154-63    I    pdf

 

Reed, J.C., Doctor, K., Rojas, A., Zapata, J.M., Stehlik, C., Fiorentino, L., Damiano, J., Roth, W., Matsuzawa, S., Newman, R., Takayama, S., Marusawa, H., Xu, F., Salvesen, G., and Godzik, A. (2003) Comparative Analysis of Apoptosis and Inflammation Genes of Mice and Humans.   Genome Res.13(6B), 1376-1388    I    pdf

 

Stehlik, C., Hayashi, H., Pio, F., Godzik, A., and Reed, J.C. (2003) CARD6, a CARD containing inhibitor of Nod1 and Cardiak induced NF-kB activation.   J. Biol. Chem. 278, 31941-31949    I    pdf

 

Stehlik, C., Krajewska, M., Welsh, K., Krajewski, S., Godzik, A., and Reed, J.C. (2003) The PAAD/PYRIN-only protein POP is a modulator of ASC-mediated NF-kB and pro-Caspase-1 regulation.   Biochem. J. 372, 101-113    I   pdf

editorial: Mariathasan, S., and Vucic, D. (2003) POPing the fire into the pyrin?   Biochem. J. 372, e1-2    I    pdf

 

 

 

2004

 

Bruey, J.M., Bruey-Sedano, N., Newman, R., Chandler, S., Stehlik, C., and Reed, J.C.  (2004) PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages.  J. Biol. Chem. 279, 51897-51907   I    pdf

 

Kroismayr, R., Baranyi, U., Stehlik, C., Dorfleutner, A., Binder, B.R., and Lipp, J. (2004) HERC5, a HECT E3 ubiquitin ligase tightly regulated in LPS activiated endothelial cells.   J. Cell Science 117, 4749-4756   I    pdf

 

Stehlik C., Kroismayr, R., Dorfleutner A., Binder B.R., and Lipp J. (2004) VIGR – a novel inducible adhesion family G-protein coupled receptor in endothelial cells.   FEBS Letters 569, 149-155   I    pdf

 

Stehlik, C*. and Reed, J.C. (2004) The PYRIN Connection: Novel Players in innate immunity and inflammation.    *Corresponding Author;   J. Exp. Med. 200, 551-558    I    pdf

 

 

 

2005

 

Chanvorachote, P., Nimmanit, U., Wang, L., Stehlik, C., Lu, B., Azad, N., and Rojanasakul, Y. (2005) Nitric oxide negatively regulates Fas (CD95)-induced apoptosis through inhibition of ubiquitin-proteasome mediated degradation of FLIP.  J. Biol. Chem. 280, 42044-42050   I    pdf

 

Medan, D., Wang, L., Toledo, D., Lu, B., Stehlik, C., Shi, X., and Rojanasakul, Y. (2005) Regulation of Fas (CD95)-mediated apoptotic and necrotic cell death by reactive oxygen species in macrophages.   J. Cell Physiol. 203,78-84   I    pdf

 

 

 

2006

 

Azad, N., Chanvorachote, P., Nimmanit, U., Stehlik, C., Ongpipatanakul, B., and Rojanasakul, Y. (2006). Reactive Oxygen Species-mediated S-Nitrosylation and stabilization of Bcl-2.   J. Biol.Chem., 281, 34124-34134   I    pdf

 

Lu, B., Wang, L., Stehlik, C., Medan, D., Huang, C., Hu, S., Chen, F., Shi, X., and Rojanasakul, Y. (2006) Phosphatidylinositol 3-Kinase/Akt Positively Regulates Fas (CD95)-Mediated Apoptosis in Epidermal Cl41 Cells.  J. Immunol. 176, 6785-6793   I    pdf

 

Chanvorachote, P., Nimmanit, U., Stehlik, C., Ongpipatanakul, B., and Rojanasakul, Y. (2006). Nitric Oxide Regulates Cell Sensitivity to Cisplatin-Induced Apoptosis through S-Nitrosylation and Inhibition of Bcl-2 Ubiquitination.   Cancer Res. 66, 6353-6360   I    pdf

 

 

 

2007

 

Stehlik, C. and Dorfleutner, A. (2007) COPs & POPs: Modulators of Inflammasome Activity.   J. Immunol., 179, 7993-7998       I    pdf

 

Dorfleutner, A., Stehlik, C., Zhang, J., Gallick, G.E., Flynn, D.C. (2007) AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells.  J. Cell. Physiol., 213, 740-749    I    pdf

 

Stehlik, C. (2007) The PYRIN domain in signal transduction.   Curr. Prot. Pept. Sci., 8, 293-310    I    pdf

 

Dorfleutner, A., Bryan, N.B., Talbott, S.J., Fynya, K.N., Rellick, S.L., Reed, J.C., Shi, X., Royanasakul, Y., Flynn, D.C., and Stehlik, C. (2007) Cellular PYRIN domain-only protein (cPOP) 2 is a novel regulator of inflammasome activation.  Infect. Immun., 75, 1484-1492    I    pdf      I    featured as a Spotlight article in Infection and Immunity    I    pdf

 

Dorfleutner, A., Talbott, S.J., Bryan, N.B., Funya, K.N., Rellick, S.L., Reed, J.C., Shi, X., Flynn, D.C, Rojanasakul, Y. and Stehlik, C. (2007) A shope Fibroma virus PYRIN-only protein modulates the host immune response.    Virus Genes., 35, 685-694       I    pdf

 

 

 

2008

 

Dorfleutner, A, Chi, Y., Vincent, D., Cunnick, J.M., Lin, H., Weed, S.A., Stehlik, C., and Flynn, D.C. (2008) Phosphorylation of AFAP-110 affects podosome lifespan in A7r5 cells.   J. Cell Sci., 121, 2394-24057   I    pdf

 

Wang; L., Chanvorachote, P., Toledo, D., Stehlik, C., Mercer, R.R., Castranova, V. and Rojanasakul, Y. (2008) Peroxide is a Key Mediator of Bcl-2 Downregulation and Apoptosis Induction by Cisplatin in Human Lung Cancer Cells.   Mol. Pharm., 73, 119-127   I    pdf

 

 

 

2009

 

Stehlik, C. (2009) Multiple proteases are responsible for IL-1β maturation in inflammatory arthritis.   Arthritis & Rheum., 60, 3524-3530   I    pdf

 

Bryan, N.B., Dorfleutner, A., Rojanasakul, Y, and Stehlik, C. (2009) Activation of inflammasomes requires intracellular redistribution of the apoptotic speck-like protein containing a caspase recruitment domain (ASC).   J. Immunol., 182, 3173-3182   I    pdf   I    featured "in this issue"   I    pdf

 

 

 

2010

 

Khare, S., Luc, N., Dorfleutner, A., and Stehlik, C. (2010) Inflammasomes and their activation.   Crit. Rev. Immunol, 30, 463-487   I    pdf

 

Azad, N., Iyer, A., Vallyathan, V., Wang, L., Castranova, V., Stehlik, C. and Rojanasakul, Y. (2010) Role of oxidative/nitrosative stress-mediated Bcl-2 regulation in apoptosis and malignant transformation.    Ann. N.Y. Acad. Sci., 1203, 1-6   I    pdf 

 

Bryan, N.B., Dorfleutner, A., Kramer, S.J., Yun, C., Rojanasakul, Y. and Stehlik, C. (2010) Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes.   J. Inflammation., 18, 7-23   I    pdf   I     Highly accessed article

 

 

 

2011

 

Iyer, A.K., Azad, N., Talbot, S., Stehlik, C., Lu, B., Wang, L. and Rojanasakul, Y. (2011) Antioxidant c-FLIP inhibits Fas ligand-induced NF-kappaB activation in a phosphatidylinositol 3-kinase/Akt-dependent manner.     J. Immunol., 187, 3256-3266   I    pdf 

 

Stehlik, C. (2011) Macrophages, the Inflammasome and IL-1β in Cancer.   The Journal of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, XIV, 44-52   I    pdf

 

 

 

2012

 

Huang, Q.Q., Koessler, R.E., Birkett, R., Dorfleutner, A., Perlman, H., Haines III, K.G., Stehlik, C., Nicchitta, C.V. and Pope, R.M., (2012) Gp96 perpetuates the Persistent Inflammation of Rheumatoid Arthritis.     Arthritis & Rheumatism, 64, 3638-3648   I    pdf

 

Khare, S., Dorfleutner, A., Bryan, N.B., Yun, C., Radian, A.D., de Almeida, L., Rojanasakul, Y., and Stehlik, C. (2012) An NLRP7-containing inflammasome mediates recognition of microbial lipopeptides in macrophages.    Immunity,  36, 464-476   I    pdf   I     Most-read article   I    pdf   I    Featured as a Research Highlight in Nature Reviews Immunology.    Nature Reviews Immunology, 12, 358   I    pdf   I    Featured as a Research Highlight in Nature Immunology.    Nature  Immunology, 13, 358    I    pdf   I    press coverage: Northwestern University   I    pdf   I    The Daily Northwestern   I    pdf   I    EurekAlert   I    pdf   I    LabSpaces   I    pdf   I    MediLexicon   I    pdf   I    Medical News Today   I    pdf   I    recommended by F1000Prime       I    pdf

 

Luanpitpong, S., Chanvorachote, P., Nimmannit, U., Leonard, S.S., Stehlik, C., Wang, L. and Rojanasakul, Y. (2012) Mitochondrial Superoxide Mediates Doxorubicin-Induced Keratinocyte Apoptosis through Oxidative Modification of ERK and Bcl-2 Ubiquitination.   Biochemical Pharmacology, 83, 1643-1654   I    pdf

 

Kung, V.L., Khare, S., Stehlik, C., Bacon, E., Hughes, A.J.,Hauser, A.R.. (2012) An rhs gene of Pseudomonas aeruginosa encodes a virulence protein that activates the inflammasome,     Proc. Nat. Acad. Sci. USA, 109, 1275-1280   I    pdf   I       Featured as a Research Highlight in Nature.   Nature, 481, 240   I    pdf

 

Shi, B., Huang, Q., Tak, P.P., Vervoordeldonk, M.J., Huang, C.C., Dorfleutner, A., Stehlik, C. and Pope, R.M. (2012) SNAPIN: an endogenous toll-like receptor ligand in rheumatoid arthritis.    Ann. Rheum. Dis., 71, 1411-1417    I    pdf

 

 

 

2013

 

Ratsimandresy, R., Dorfleutner, A., Stehlik, C. (2013) An Update on PYRIN Domain-Containing Pattern Recognition Receptors: From Immunity to Pathology.    Front. Immunol., 4:440   I    pdf

 

Radian, A.D., Dorfleutner, A., de Almeida, L., and Stehlik, C. (2013) NLRP7 and related inflammasome activating pattern recognition receptors and their function in host defense and disease.    Microbes & Infection, 15, 630-639   I    pdf

 

Luanpitpong, S., Chanvorachote, P., Stehlik, C., Tse, W., Callery, P.S., Wang, L., and Rojanasakul, Y. (2013) Regulation of Apoptosis by Bcl-2 Cysteine Oxidation in Human Lung Epithelial Cells.     Mol. Biol. Cell, 24, 858-869   I    pdf

 

 

 

2014

 

Khare, S., Ratsimandresy, R.A., de Almeida, L., Cuda, C.M., Rellick, S.L., Misharin, A.V., Wallin, M.C., Gangopadhyay, A., Forte, E., Gottwein, E., Perlman, H., Reed, J.C., Greaves, D.R., Dorfleutner, A. and Stehlik, C. (2014) The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses.   Nature Immunology, 15, 343-353   I    pdf   I    highlighted with a News and Views Commentary by Krishnaswamy J.K., Liu D. and Eisenbarth S.C. (2014) POP goes the inflammasome.   Nature Immunology, 15, 311-313   I    pdf   I    selected as the cover article   I    pdf   I    featured by the Austrian Presse Agentur (APA) and MedOnline   I    pdf   I    jimdo.com (in Italian)   I    pdf   I    Nature Asia   I    pdf   I    and Feinberg News   I    pdf

 

Talbott, S.J., Luanpitpong, S., Stehlik, C., Azad, N., Iyer, A.K.V., Wang, L. and Rojanasakul, Y. (2014) S-nitrosylation of FLICE inhibitory protein determines its interaction with RIP1 and activation of NF-κB.    Cell Cycle, 13, 1948-1957   I    pdf

 

Cuda, C.M., Misharin, A.V., Gierut, A.K., Saberr, R., Haines, G.K., Hutcheson, J., Hedrick, S.M., Mohan, C., Budinger, G.S., Stehlik, C., Perlman, H. (2014) Caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated Dendritic Cell activation.    J. Immunol., 192, 5548-5560   I    pdf   I     featured "in this issue"   I    pdf

 

 

 

2015

 

de Almeida, L., Khare, S., Misharin, A.V., Patel, R., Wallin, M., Perlman, H.R., Greaves, D.R., Hoffman, H.M., Dorfleutner, A., and Stehlik, C. (2015) The PYRIN domain-only protein POP1 inhibits inflammasome assembly and ameliorates inflammatory disease.   Immunity 43, 264-276   I    pdf   I       Selected for display at the Immunity website   I    pdf   I    highlighted with a Commentary by Shimada K. Timothy R. Crother T.R., and Arditi, M. (2015) POPsicle for Fever! Cooling Down the Inflammasome.   Immunity, 43, 213-215   I    pdf   I    press coverage: Northwestern University   I    pdf   I    the Rheumatologist   I    pdf

 

Cuda, C.M., Misharin, A.V., Khare, S., Saber, R., Tsai, F., Archer, A.M., Homan, P.J., Haines III, K.G, Hutcheson, J., Dorfleutner, A., Budinger, S.G.R., Stehlik, C. and Perlman, H. (2015) Conditional deletion of caspase-8 in macrophages alters macrophage activation in a RIPK-dependent manner. Arthritis Research & Therapy, 17, 291-307   I    pdf

 

Radian, A.D., Khare, S., Chu, L.H., Dorfleutner, D. and Stehlik, C. (2015) ATP binding by NLRP7 is required for inflammasome activation in response to bacterial lipopeptides,    Molecular Immunology, 2015, pii: S0161-5890(15)00437-X   I    pdf

 

Chu, L.H., Gangopadhyay, A., Dorfleutner, A. and Stehlik, C. (2015) An updated view on the structure and function of PYRIN domains.    Apoptosis, 20,157-173   I    pdf

 

Dorfleutner, A. Chu, L. and Stehlik, C. (2015) Inhibiting the inflammasome: one domain at a time.   Immunol. Rev., 265, 205-216   I    pdf

 

Thorp, E.B., Stehlik, C. and Ansari, M.J. (2015) T-cell exhaustion in allograft rejection and tolerance.    Curr. Opin. Organ. Transplant., 20, 37-42   I    pdf

 

Queen, J., Agarwal, S., Dolores, J., Stehlik, C. and Satchell, K.J.F. (2015) Mechanisms of inflammasome activation by Vibrio cholerae secreted toxins varies with strain biotype.   Infection & Immunity, 83, 2496-2506   I    pdf

 

 

 

2016

 

Khare, S. Radian, A.D., Dorfleutner, A. and Stehlik, C. (2016) Methods to measure NLR oligomerization: co-immunoprecipitation and cross-linking. in “NLR proteins: Methods and Protocols”,    Methods in Molecular Biology, Humana Press, Francesco Di Virgilio, Pablo Pelegrín (Eds.), 2016.   I    pdf

 

de Almeida, L., Dorfleutner, A. and Stehlik, C. (2016)  ASC-Particle-Induced Peritonitis. Bio-protocol  6(19): e1944. DOI: 10.21769/BioProtoc.1944.   I    pdf  .

 

de Almeida, L., Dorfleutner, A. and Stehlik, C. (2016) LPS-Induced Peritonitis. Bio-protocol 6(19): e1945. DOI: 10.21769/BioProtoc.1945.   I    pdf  .

 

Dorfleutner, A. and Stehlik, C. (2016)  A dRAStic RHOAdblock of Pyrin inflammasome activation. Nature Immunol., 17. 900-902.   I    pdf

 

 

 

2017

 

Ratsimandresy, R.A., Indramohan, M., Dorfleutner, A. and Stehlik, C. (2017)  The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway.    Cellular & Molecular Immunol., 13, 127–142.   I    pdf

 

Shi, B., Huang, Q., Birkett, R., Doyle, R., Dorfleutner, A., Stehlik, C., He, C. and Pope, R.M. (2017) Snapin is critical for lysosomal acidification and autophagosome maturation in macrophages.   Autophagy 13, 285-301.   I    pdf

 

Ratsimandresy, R., Chu, H.L., Indramohan, M., Gangopadhyay, A., Dorfleutner, A., and Stehlik, C. (2017) The PYRIN domain-only protein POP2 regulates inflammasome priming and activation.    Nature Communications 8, 15556.   I    pdf.   I    press coverage: Northwestern University   I    pdf   I

 

Tsai, F., Homan, P.J., Agrawal, H., Misharin,A.V., Abdala-Valencia, H., Haines III, K.G., Dominguez, S., Bloomfield, C., Saber, R., Chang, A., Mohan, C., Hutcheson, J., Davidson, A.,  Budinger, S.G., Bouillet, P., Dorfleutner, A., Stehlik, C., Winter, D.R., Cuda, C.M.,and  Perlman, H. (2017)  Bim Suppresses the Development of SLE by limiting Myeloid Inflammatory Responses.   J. Exp. Med. 214, 3753-3773.   I    pdf

 

 Indramohan, M., Stehlik, C., and Dorfleutner, A. (2017)  COPs and POPs patrol inflammasome activation.   J. Mol. Biol. S0022-2836(17)30474-6.  I    pdf

 

 

 

2018

 

 Viaud, M., Ivanov, S., Vujic, N., Duta-Mare, M., Aira, L.E., Barouillet, T., Garcia, E., Orange, F., Dugail, I., Hainault, I., Stehlik, C., Marchetti, S., Boyer, L., Guinamard, R., Foufelle, F., Bochem, A., Hovingh, K.G., Thorp, E.B., Gautier, E.L., Kratky, D., Dasilva-Jardine, P., Yvan-Charvet, L. (2018) Lysosomal Cholesterol Hydrolysis Couples Efferocytosis to Anti-Inflammatory Oxysterol Production.   Circulation Res. in press.   I    pdf

 

 Chu, H.L., Indramohan, M., Ratsaimandresy, R.A., Gangopadhyay, A., Morris, E.P., Monack, D.M., Dorfleutner, A., and Stehlik, C. (2018) The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages.   Nature Communications 9, 996.  I    pdf    I    press coverage: Northwestern University   I    pdf   I

 

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